Reaktion #60698

Reaktionsgleichung

3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)-ethyl]-1H-indole-6-carboxamide hydrochloride

[(1-ethoxycyclopropyl)oxy]trimethylsilane

→

3-Chloro-N-[(R)-1-phenyl-2-(1-cyclopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeafforded
2. 2
   Sonstigeafter purification (SiO2: 0 to 5% isopropylamine in 10:2:2:DCM:EtOAc:hexane)

Vorschrift

Using alkylation method A with addition of 3A molecular sieves, 3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)-ethyl]-1H-indole-6-carboxamide hydrochloride (200 mg, 0.44 mmol) and [(1-ethoxycyclopropyl)oxy]trimethylsilane (0.53 mL, 2.7 mmol) afforded, after purification (SiO2: 0 to 5% isopropylamine in 10:2:2:DCM:EtOAc:hexane) and after conversion to the HCl salt by general method B, 80 mg (40%) of the title compound.

Quelle