Reaktion #60673

ord-19cf9f219fcc4f72a7ef87e51f84041f

Reaktionsgleichung

CN1C(=O)N(CC2(CS(=O)(=O)N3CCC(Oc4ccc(Cl)cn4)CC3)NC(=O)NC2=O)C(=O)C1(C)C
5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione
Cl.Clc1ccc(OC2CCNCC2)nc1
5-Chloro-2-(piperidine-4-yloxy)-pyridine hydrochloride
O=C1NC(=O)C(CCOCc2ccccc2)(CS(=O)(=O)Cl)N1
(2,5-dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride
→
O=C1NC(=O)C(CCOCc2ccccc2)(CS(=O)(=O)N2CCC(Oc3ccc(Cl)cn3)CC2)N1
title compound
O=C1NC(=O)C(CCOCc2ccccc2)(CS(=O)(=O)N2CCC(Oc3ccc(Cl)cn3)CC2)N1
5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-{2-[(phenylmethyl)oxy]ethyl}imidazolidine-2,4-dione

Edukte

CN1C(=O)N(CC2(CS(=O)(=O)N3CCC(Oc4ccc(Cl)cn4)CC3)NC(=O)NC2=O)C(=O)C1(C)C
5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione
Cl.Clc1ccc(OC2CCNCC2)nc1
5-Chloro-2-(piperidine-4-yloxy)-pyridine hydrochloride
O=C1NC(=O)C(CCOCc2ccccc2)(CS(=O)(=O)Cl)N1
(2,5-dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared as described in the synthesis of 5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione starting from 5-Chloro-2-(piperidine-4-yloxy)-pyridine hydrochloride and (2,5-dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427631B2uspto-grants-2008_09