Reaktion #60639

Reaktionsgleichung

N-(3-nitro-phenyl)-guanidine nitrate

1-(2-ethylamino-4-methyl-thiazol-5-yl)-ethanone

3-chloro-pentane-2,4-dione

→

title compound

[4-(2-Ethylamino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine

Reaktionsbedingungen

Vorschrift

3-Dimethylamino-1-(2-ethylamino-4-methyl-thiazol-5-yl)-propenone was prepared by reaction between 1-(2-ethylamino-4-methyl-thiazol-5-yl)-ethanone and 3-chloro-pentane-2,4-dione. It was then condensed with N-(3-nitro-phenyl)-guanidine nitrate in the usual manner to afford the title compound. Yellow solid; 1H-NMR (DMSO-d6) δ: 1.14 (m, 3H, CH3), 2.47 (s, 3H, CH3), 3.23 (m, 2H, CH2), 6.99 (d, 1H, J=5.0 Hz, pyrimidinyl-H), 7.55 (m, 1H, Ph-H), 7.77 (m, 1H, Ph-H), 8.02 (m, 1H, Ph-H), 8.39 (d, 1H, J=5.0 Hz, pyrimidinyl-H), 8.47 (s, 1H, Ph-H), 9.98 (br. s, 1H, NH).

Quelle