Reaktion #60589

Reaktionsgleichung

2-benzoylmorpholine hydrochloride

2-chloro-3-methyl-6-(4-pyridyl)-pyrimidine-4-one

triethylamine

→

title compound

Ausbeute 101.5%

2-(2-benzoylmorpholin-4-yl)-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one

Ausbeute 101.5%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered off
2. 2
   Temperaturafter cooling
3. 3
   Sonstigesolvent was removed in vacuo
4. 4
   WaschenThe residue was washed with refluxing ethyl acetate and diethyl ether

Vorschrift

A solution of 2-benzoylmorpholine hydrochloride (269 mg, 1.17 mmol), 2-chloro-3-methyl-6-(4-pyridyl)-pyrimidine-4-one (320 mg, 1.41 mmol) and triethylamine (0.49 ml, 3.51 mmol) in tetrahydrofuran (10 ml) was refluxed for several hours. The precipitate was filtered off after cooling and solvent was removed in vacuo. The residue was washed with refluxing ethyl acetate and diethyl ether to give the title compound (447 mg, quant.).

Quelle