Reaktion #60540

Reaktionsgleichung

4-[4-methyl-2-(3,3,5,5-tetramethylcyclohexyl)phenyl]-1-propyl-1,2,3,6-tetrahydropyridine hydrochloride

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title compound

Ausbeute 31.4%

4-[4-Methyl-2-(3,3,5,5-tetramethylcyclohexyl)phenyl]-1-propylpiperidine hydrochloride

Ausbeute 31.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through Celite
2. 2
   Einengenthe obtained filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONHexane was added to the residue
4. 4
   Sonstigeto produce a solid, which
5. 5
   Sonstigewas then triturated by sonication
6. 6
   FiltrationThe solid was filtered
7. 7
   Sonstigedried under reduced pressure

Vorschrift

To a solution of 4-[4-methyl-2-(3,3,5,5-tetramethylcyclohexyl)phenyl]-1-propyl-1,2,3,6-tetrahydropyridine hydrochloride (50 mg, 0.13 mmol) produced in Example (104g) in methanol (10 mL) was added 10% palladium on carbon (50 mg, wet), followed by stirring for 2 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated under reduced pressure. Hexane was added to the residue to produce a solid, which was then triturated by sonication. The solid was filtered and dried under reduced pressure to give 16 mg of the title compound as a light yellow solid.

Quelle