Reaktion #60461

Reaktionsgleichung

1-[2-(4-t-butylcyclohexyl)phenyl]piperazine

methyl acrylate

→

title compound

Ausbeute 94.5%

3-[4-[2-(4-t-Butylcyclohexyl)phenyl]piperazin-1-yl]propionic acid methyl ester

Ausbeute 94.5%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   Sonstigethe resultant residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

To a mixture of 1-[2-(4-t-butylcyclohexyl)phenyl]piperazine (530 mg, 1.76 mmol) produced in Example (10a) and tetrahydrofuran (2 mL) was added methyl acrylate (0.24 mL, 2.65 mmol), followed by stirring for 12 hours at an external temperature of 45° C. The reaction mixture was concentrated under reduced pressure and the resultant residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give 643 mg of the title compound as colorless crystals, as a mixture of diastereomers at the position of t-butylcyclohexyl.

Quelle