Reaktion #604547

Reaktionsgleichung

3-hydrazinopyridine

sodium ethoxide

diethyl maleate

→

ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare introduced into a reaction vessel
2. 2
   Sonstigehas reacted
3. 3
   Temperaturto cool

Vorschrift

In a preferred reaction, sodium ethoxide in an anhydrous ethanol are introduced into a reaction vessel and 3-hydrazinopyridine•dihydrochloride is added. The mixture is stirred and diethyl maleate is added. The mixture is heated at about 60° C. until most of the 3-hydrazinopyridine has reacted. The mixture is allowed to cool and the excess base is neutralized with acid. The crude ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate (10a) is conveniently isolated and purified by standard techniques.

Quelle