Reaktion #60439

Reaktionsgleichung

1-[4-bromo-2-(4,4-dimethylcyclohexyl)phenyl]-4-butylpiperazine

(R)-3-methoxypiperidine hydrochloride

tripotassium phosphate

tri-t-butylphosphonium tetrafluoroborate

→

(R)-1-butyl-4-[2-(4,4-dimethylcyclohexyl)-4-(3-methoxypiperidin-1-yl)phenyl]piperazine

Ausbeute 59.2%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was air-cooled to room temperature
2. 2
   Sonstigepurified by NH silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

A mixture of 1-[4-bromo-2-(4,4-dimethylcyclohexyl)phenyl]-4-butylpiperazine (37.4 mg, 0.0918 mmol) produced in Example (21c), (R)-3-methoxypiperidine hydrochloride (16.7 mg, 0.110 mmol) produced in Example (49a), tripotassium phosphate (170 mg, 0.801 mmol), palladium(II) acetate (8.2 mg, 0.0365 mmol), tri-t-butylphosphonium tetrafluoroborate (32 mg, 0.110 mmol) and xylene (1.5 mL) was stirred for 4 hours and 30 minutes at an external temperature of 100° C. under a nitrogen atmosphere. The mixture was air-cooled to room temperature and then purified by NH silica gel column chromatography (ethyl acetate/hexane) to give 24 mg of (R)-1-butyl-4-[2-(4,4-dimethylcyclohexyl)-4-(3-methoxypiperidin-1-yl)phenyl]piperazine as a colorless oil.

Quelle