Reaktion #60366

ord-e712505069774998bf9341b5d9f346b9

Reaktionsgleichung

CN1c2cc(CO)ccc2C(NC(=O)CC(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O
N-(7-hydroxymethyl-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazin-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide
CS(=O)(=O)[O-]
mesylate
C1CCNCC1
piperidine
→
CN1c2cc(CN3CCCCC3)ccc2C(NC(=O)CC(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O
title compound
CN1c2cc(CN3CCCCC3)ccc2C(NC(=O)CC(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O
3-(Naphthalen-2-yl-sulfonylamino)-N-(1-methyl-2,2-dioxo-7-piperidin-1-ylmethyl-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazin-4-yl)-3-phenyl-propionamide

Edukte

CN1c2cc(CO)ccc2C(NC(=O)CC(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O
N-(7-hydroxymethyl-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazin-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide
CS(=O)(=O)[O-]
mesylate
C1CCNCC1
piperidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from N-(7-hydroxymethyl-1-methyl-2,2-dioxo-1,2,3,4-tetrahydro-2λ6-benzo[c][1,2]thiazin-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide (Example 12, Step D) via its mesylate and addition of piperidine by a method similar to that described in Example 12, Step E. MS (+ESI, m/z): 647 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07425631B2uspto-grants-2008_09