Reaktion #603231

Reaktionsgleichung

3,3,3-trifluoro-1-nitroprop-1-ene

benzylamine

→

title compound

Ausbeute 78.0%

N-Benzyl-1,1,1-trifluoro-3-nitropropan-2-amine

Ausbeute 78.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated
2. 2
   Sonstigethe residue was purified by column chromatography (EtOAc/PE=1/10)

Vorschrift

A mixture of 3,3,3-trifluoro-1-nitroprop-1-ene (4 g, 28.4 mmol) and benzylamine (3.2 g, 30.0 mmol) in toluene (50 mL) was stirred for RT or 1 h. The mixture was concentrated and the residue was purified by column chromatography (EtOAc/PE=1/10) to give the title compound (5.5 g, 78%). 1H NMR (400 MHz, CDCl3) δ ppm 3.91-3.95 (m, 1 H), 4.06-4.14 (m, 1 H), 4.45-4.51 (m, 1 H), 4.63-4.67 (m, 1 H), 7.30-7.39 (m, 5 H).

Quelle