Reaktion #602749

Reaktionsgleichung

ortho-chloranil

ethyl 4-[6-chloro-2-phenylimidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate

sodium hydroxide

→

beige powder

Ausbeute 71.2%

6-chloro-2-phenyl-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

Ausbeute 71.2%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe product is extracted with chloroform
2. 2
   TrocknenThe organic phase is dried over sodium sulfate
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   SonstigeThe dark beige residue is crystallized from a mixture of 80 ml of isopropanol and 60 ml of diisopropyl ether under hot conditions

Vorschrift

22.3 g (58.4 mmol) of ethyl 4-[6-chloro-2-phenylimidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate are dissolved in 450 ml of chloroform and 15.1 g (61.3 mmol) of ortho-chloranil are added portionwise. The reaction medium is stirred for 30 minutes at ambient temperature and then poured into a 2N aqueous solution of sodium hydroxide. The product is extracted with chloroform. The organic phase is dried over sodium sulfate and then concentrated under reduced pressure. The dark beige residue is crystallized from a mixture of 80 ml of isopropanol and 60 ml of diisopropyl ether under hot conditions, to give 12.8 g of a beige powder after cooling, isolation by filtration and drying.

Quelle