Reaktion #602747

Reaktionsgleichung

6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

2-hydroxyethylpiperazine

→

2-{4-[2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol

Lösungsmittel

pentanol

Reaktionsbedingungen

Vorschrift

The mixture of 0.26 g (0.8 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and 0.425 g (3.2 mmol) of 2-hydroxyethylpiperazine in 4 ml of pentanol is heated in a sealed tube at 130° C. for 32 hours.

Quelle