Reaktion #602469

Reaktionsgleichung

4-(Bromomethyl)-2-fluoro-1-nitrobenzene

triethyl phosphite

→

title compound

Diethyl 3-fluoro-4-nitrobenzylphosphonate

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with diethyl ether
2. 2
   TrocknenThe organics were dried with magnesium sulphate
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated under reduced pressure

Vorschrift

4-(Bromomethyl)-2-fluoro-1-nitrobenzene (34.72 g, 148 mmol) and triethyl phosphite (25.8 mL) were heated at 140° C. for 4 hours. Water was added and the mixture was extracted with diethyl ether. The organics were dried with magnesium sulphate, filtered and evaporated under reduced pressure to afford the title compound (40.94 g). 1H NMR (CDCl3, 400 MHz): δ 8.03 (t, 1H), 7.24 (s, 1H) 7.21 (s, 1H) 4.08 (m, 4H), 3.20 (d, 2H), 1.27 (m, 6H)

Quelle