Reaktion #60218

Reaktionsgleichung

2,4-dichlorophenacyl chloride

phthalimide

Cs2CO3

→

2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dione

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONdiluted with water and ethyl acetate
3. 3
   EinengenThe ethyl acetate layer was concentrated
4. 4
   Sonstigepurified by trituration with diethyl ether

Vorschrift

1 mmol of 2,4-dichlorophenacyl chloride in DMF was added drop wise to 2 mmol of phthalimide and 2 mmol of Cs2CO3 in DMF at room temperature for fourteen hours and then the reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The ethyl acetate layer was concentrated and then purified by trituration with diethyl ether.

Quelle