Reaktion #601671

Reaktionsgleichung

(2-bromo-4-fluorophenyl)methanol

4-fluoro-1-vinylbenzene

Et3N

→

title compound

Ausbeute 50.0%

[4-fluoro-2-[(E)-2-(4-fluorophenyl)ethenyl]phenyl]methanol

Ausbeute 50.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe mixture was then purged with nitrogen
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Extraktionthe filtrate was then extracted with ethyl acetate
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by flash column chromatograph

Vorschrift

Charged (2-bromo-4-fluorophenyl)methanol (954 mg, 4.65 mmol), 4-fluoro-1-vinylbenzene (1.14 g, 9.31 mmol), Pd(PPh3)2Cl2 (49 mg, 0.07 mmol), Et3N (942 mg, 9.31 mmol) and DMF (5 mL) to a sealed tube, the mixture was then purged with nitrogen, heated to 150° C. for 3 h in microwave oven. The reaction mixture was filtered, the filtrate was then extracted with ethyl acetate, concentrated and purified by flash column chromatograph to give 569 mg of the title compound (50%). 1H NMR (400 MHz, CDCl3): δ 1.60 (1H, t, J=6.4 Hz), 4.78 (2H, d, J=6.4 Hz), 6.93-7.08 (4H, m), 7.31-7.35 (3H, m), 7.48-7.52 (2H, m).

Quelle