Reaktion #600479

Reaktionsgleichung

tert-butyl-3-iodobenzylcarbamate

(1S,2S)—N1,N2-dimethylcyclohexane-1,2-diamine

pyrazole

K2CO3

→

tert-butyl-3-(1H-pyrazol-1-yl)benzylcarbamate

Ausbeute 70.3%

Lösungsmittel

Dioxane

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenit was concentrated
2. 2
   Sonstigethe residue was purified by column chromatography

Vorschrift

To a solution of tert-butyl-3-iodobenzylcarbamate (550 mg, 1.65 mmol) in Dioxane (1.2 mL) and DMSO (1.2 mL) was added CuI (16 mg, 0.083 mmol), (1S,2S)—N1,N2-dimethylcyclohexane-1,2-diamine (0.052 ml, 0.33 mmol), pyrazole (135 mg, 1.98 mmol) and K2CO3 (479 mg, 3.47 mmol). After stirring at 120° C. for 3 h, it was concentrated and the residue was purified by column chromatography to give tert-butyl-3-(1H-pyrazol-1-yl)benzylcarbamate (317 mg).

Quelle