Reaktion #600388

Reaktionsgleichung

tert-butyl 7-chloro-3-(2-hydroxyethyl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

4-trifluoromethoxyphenol

triphenylphosphine

diisopropylazodicarboxylate

→

title product

Ausbeute 96.7%

tert-butyl 7-chloro-3-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Ausbeute 96.7%

Lösungsmittel

PhMe

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated in vacuo
2. 2
   Sonstigethe crude material was purified on silica (gradient elution, 0-30% EtOAc/hexanes)

Vorschrift

To a solution of tert-butyl 7-chloro-3-(2-hydroxyethyl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (233 mg, 0.79 mmol) in PhMe (15 mL) was added 4-trifluoromethoxyphenol (0.15 mL, 1.2 mmol), triphenylphosphine (309 mg, 1.2 mmol), and diisopropylazodicarboxylate (0.23 mL, 1.2 mmol) at r.t. After 20 min, the mixture was concentrated in vacuo, and the crude material was purified on silica (gradient elution, 0-30% EtOAc/hexanes) to yield the title product (349 mg). HRMS (ESI) calc (M+H)+=457.1136. found 457.1133.

Quelle