Reaktion #60031

Reaktionsgleichung

2,4-dichlorobenzoyl chloride

n-propyl magnesium chloride

→

1-(2,4-dichlorophenyl)butan-1-one

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTen minutes after addition
2. 2
   Sonstigethe cooling bath was removed
3. 3
   workup.ADDITIONWater was carefully added
4. 4
   Extraktionfollowed by extraction with toluene
5. 5
   WaschenThe toluene layer was washed with dilute HCl, water, saturated sodium bicarbonate solution
6. 6
   Sonstigedried
7. 7
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 2,4-dichlorobenzoyl chloride (4.5 g) and copper (I) iodide (200 mg) in dry THF (30 ml) was cooled to −20° C. under argon. Then a solution of n-propyl magnesium chloride (2 M in ether, 11.0 ml) was added dropwise. Ten minutes after addition was complete, the cooling bath was removed and the mixture stirred for 1 hour. Water was carefully added, followed by extraction with toluene. The toluene layer was washed with dilute HCl, water, saturated sodium bicarbonate solution, dried and concentrated in vacuo to give 1-(2,4-dichlorophenyl)butan-1-one (4.0 g).

Quelle