Reaktion #59984

Reaktionsgleichung

( 14e )

2-(((4-(((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ol

→

title compound

2-(((4-((3,3-dimethyl-1,5-dioxaspiro[5.5]undec-9-yl)oxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step (81a) above

Vorschrift

The same procedure as in the steps (14a) to (14e) of Example 14 was repeated using the 3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-ol obtained in the step (81a) above to obtain the title compound (275 mg, the total yield of 5 steps: 3.3%) as a white solid. Note that in the same process as in the step (14b), after acetic anhydride was added, 10 equivalents of triethylamine relative to pyridine1-oxide derivative was added to perform the reaction. In the same process as in the step (14c), tetrahydrofuran was used as a solvent instead of ethanol.

Quelle