Reaktion #599729

Reaktionsgleichung

4-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

5-amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 90 min
2. 2
   EinengenThe reaction mixture was concentrated in vacuo
3. 3
   Sonstigethe resulting solids were collected
4. 4
   Waschenwashed with EtOAc

Vorschrift

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

Quelle