Reaktion #599721

Reaktionsgleichung

6-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

Ausbeute 65.4%

5-amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

Ausbeute 65.4%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 90 min
2. 2
   EinengenThe reaction mixture was concentrated in vacuo
3. 3
   Sonstigethe residue was purified by silica gel column chromatography
4. 4
   Wascheneluted with 2% MeOH in DCM

Vorschrift

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

Quelle