Reaktion #599706

Reaktionsgleichung

2-amino-2-cyanoacetamide

1-isothiocyanatonaphthalene

→

titled compound

Ausbeute 48.7%

5-amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide

Ausbeute 48.7%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 30 min
2. 2
   SonstigeThe solvent was evaporated under reduced pressure
3. 3
   Sonstigethe resulting crude residue was purified by silica gel column chromatography
4. 4
   Wascheneluted with 2% MeOH in DCM

Vorschrift

To a suspension of 2-amino-2-cyanoacetamide (0.25 g, 2.53 mmol) in EtOAc (8 mL), was added 1-isothiocyanatonaphthalene (0.467 g, 2.53 mmol), and the mixture was refluxed for 30 min. The solvent was evaporated under reduced pressure, and the resulting crude residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.35 g (48% yield) of the titled compound.

Quelle