Reaktion #59966

Reaktionsgleichung

( 4j )

2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3-chloroperbenzoic acid

1,3-dioxolan-2-ylmethanol

→

title compound

Ausbeute 17.2%

2-(((4-(1,3-dioxolan-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

Ausbeute 17.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step (66b) above

Vorschrift

The same procedure as in the steps (4f) to (4j) described in Example (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using 1,3-dioxolan-2-ylmethanol obtained in the step (66b) above to obtain the title compound (411 mg, total 17.2% yield) as a white solid.

Quelle