Reaktion #59964

Reaktionsgleichung

( 4j )

2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3-chloroperbenzoic acid

(2,2-diethyl-1,3-dioxolan-4-yl)methanol

→

title compound

Ausbeute 14.3%

2-(((4-((2,2-diethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

Ausbeute 14.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in the step (65b) above

Vorschrift

The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using (2,2-diethyl-1,3-dioxolan-4-yl)methanol obtained in the step (65b) above to obtain the title compound (418 mg, total 14.3% yield) as a light yellow solid.

Quelle