Reaktion #59962

Reaktionsgleichung

( 4j )

2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3-chloroperbenzoic acid

4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan

→

title compound

Ausbeute 8.7%

2-(((4-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

Ausbeute 8.7%

Reaktionsbedingungen

Vorschrift

The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan to obtain the title compound (412 mg, total yield: 8.7%) as a light yellow solid.

Quelle