Reaktion #5996

Reaktionsgleichung

phenol

(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy -6-methoxy-3-isoquinolinecarboxylic acid, ethyl ester

4-methoxy-3-methyl benzyl chloride

→

(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy -5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product is purified by silica gel chromatography

Vorschrift

This compound is prepared from the phenol derivative of Example 31 and 4-methoxy-3-methyl benzyl chloride by a procedure similar to that in Example 32. The product is purified by silica gel chromatography; tlc (1:1 ethyl-acetate/hexane), one spot, Rf 0.7.

Quelle