Reaktion #59958

Reaktionsgleichung

5-fluoro-1H-benzimidazole-2-thiol

( 11i )

2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

solketal

4-chloro-2,3-dimethylpyridine 1-oxide

→

title compound

Ausbeute 14.1%

2-(((4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-5-fluoro-1H-benzimidazole sodium salt

Ausbeute 14.1%

Reaktionsbedingungen

Vorschrift

The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).

Quelle