Reaktion #599524

ord-e7da28ddac3d426b97d1415ee799f010

Reaktionsgleichung

O=C(O)c1cccc(Cl)c1Cl
2,3-dichlorobenzoic acid
Cc1ncc(C(CN)C2CCC(F)(F)CC2)cn1
2-(4,4-difluorocyclohexyl)-2-(2-methylpyrimidin-5-yl)ethanamine
→
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)C2CCC(F)(F)CC2)cn1
2,3-dichloro-N-(2-(4,4-difluorocyclohexyl)-2-(2-methylpyrimidin-5-yl)ethyl)benzamide

Edukte

O=C(O)c1cccc(Cl)c1Cl
2,3-dichlorobenzoic acid
Cc1ncc(C(CN)C2CCC(F)(F)CC2)cn1
2-(4,4-difluorocyclohexyl)-2-(2-methylpyrimidin-5-yl)ethanamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From 2,3-dichlorobenzoic acid and 2-(4,4-difluorocyclohexyl)-2-(2-methylpyrimidin-5-yl)ethanamine. LCMS (MH+): m/z=448.1, tR (minutes, Method F)=2.95

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09102591B2uspto-grants-2015_08