Reaktion #599500

ord-b48606a02d13421889060babfc841a2c

Reaktionsgleichung

O=C(O)c1cccc(F)c1Cl
2-chloro-3-fluorobenzoic acid
NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1
3-(1-(trifluoromethyl)cyclopropyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)propan-1-amine
→
O=C(NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1)c1cccc(F)c1Cl
2-chloro-3-fluoro-N-(3-(1-(trifluoromethyl)cyclopropyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)propyl)benzamide

Edukte

O=C(O)c1cccc(F)c1Cl
2-chloro-3-fluorobenzoic acid
NCC(CC1(C(F)(F)F)CC1)c1cnc(C(F)(F)F)nc1
3-(1-(trifluoromethyl)cyclopropyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)propan-1-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From 2-chloro-3-fluorobenzoic acid and 3-(1-(trifluoromethyl)cyclopropyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)propan-1-amine. LCMS (MH+): m/z=470.0, tR (minutes, Method F)=3.07

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09102591B2uspto-grants-2015_08