Reaktion #59950

Reaktionsgleichung

( 1g )

2-(((4-((5,5-dimethyl-1,3-dioxan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

4-chloro-2,3-dimethylpyridine 1-oxide

(5,5-difluoro-1,3-dioxan-2-yl)methanol

→

title compound

Ausbeute 22.7%

2-(((4-((5,5-difluoro-1,3-dioxan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

Ausbeute 22.7%

Reaktionsbedingungen

Vorschrift

The same procedure as in the steps (1c) to (1g) of Example 1 was repeated using 4-chloro-2,3-dimethylpyridine 1-oxide and (5,5-difluoro-1,3-dioxan-2-yl)methanol to obtain the title compound (375 mg, 5 steps: 22.7%) as a white powder.

Quelle