Reaktion #599486

ord-1ed364261331453880a66cce983466a2

Reaktionsgleichung

O=C(O)c1c(F)cccc1Cl
2-chloro-6-fluorobenzoic acid
Cc1ncc(C(CN)c2ccncc2)cn1
2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethanamine
→
Cc1ncc(C(CNC(=O)c2c(F)cccc2Cl)c2ccncc2)cn1
2-chloro-6-fluoro-N-(2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethyl)benz amide

Edukte

O=C(O)c1c(F)cccc1Cl
2-chloro-6-fluorobenzoic acid
Cc1ncc(C(CN)c2ccncc2)cn1
2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethanamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From 2-chloro-6-fluorobenzoic acid and 2-(2-methylpyrimidin-5-yl)-2-(pyridin-4-yl)ethanamine. LCMS (MH+): m/z=371.1, tR (minutes, Method F)=1.65

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09102591B2uspto-grants-2015_08