Reaktion #59948

Reaktionsgleichung

2,2-difluoropropane-1,3-diol

benzyloxyacetaldehyde

p-toluenesulfonic acid monohydrate

→

title compound

Ausbeute 42.8%

2-((benzyloxy)methyl)-5,5-difluoro-1,3-dioxane

Ausbeute 42.8%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux by a condenser
3. 3
   Sonstigeequipped with a Dean-Stark apparatus for one hour
4. 4
   Einengenthe reaction mixture was concentrated under reduced pressure
5. 5
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
6. 6
   workup.ADDITIONsilica gel was added
7. 7
   EinengenThe resultant mixture was concentrated to dryness
8. 8
   Waschensubjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=10/1)

Vorschrift

A mixture of 2,2-difluoropropane-1,3-diol (1 g, 8.9 mmol), benzyloxyacetaldehyde (1.34 g, 8.9 mmol), p-toluenesulfonic acid monohydrate (154 mg, 0.81 mmol) and toluene (20 ml) was heated under reflux by a condenser equipped with a Dean-Stark apparatus for one hour. The resultant mixture was stirred at room temperature overnight and then the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and silica gel was added thereto. The resultant mixture was concentrated to dryness and subjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=10/1) to obtain the title compound (930 mg, 42.8%).

Quelle