Reaktion #599439

ord-2dcce7944d594738baaf4515304177cc

Reaktionsgleichung

O=C(O)c1cccc(Cl)c1Cl
2,3-dichlorobenzoic acid
Cc1ncc(C(CN)CC2(C(F)(F)F)CC2)cn1
2-(2-methyl-pyrimidin-5-yl)-3-(1-trifluoromethyl-cyclopropyl)-propylamine
→
Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)CC2(C(F)(F)F)CC2)cn1
2,3-Dichloro-N-[2-(2-methylpyrimidin-5-yl)-3-[1-(trifluoromethyl)cyclopropyl]propyl]benzamide

Edukte

O=C(O)c1cccc(Cl)c1Cl
2,3-dichlorobenzoic acid
Cc1ncc(C(CN)CC2(C(F)(F)F)CC2)cn1
2-(2-methyl-pyrimidin-5-yl)-3-(1-trifluoromethyl-cyclopropyl)-propylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From 2,3-dichlorobenzoic acid and 2-(2-methyl-pyrimidin-5-yl)-3-(1-trifluoromethyl-cyclopropyl)-propylamine. LCMS (MH+): m/z=377.1, tR (minutes, Method F)=1.68

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09102591B2uspto-grants-2015_08