Reaktion #59942

Reaktionsgleichung

3-hydroxy-2-oxopropyl benzoate

1,3-propanediol

triethyl orthoformate

3-hydroxy-2-oxopropyl benzoate

1,3-propanediol

triethyl orthoformate

p-toluenesulfonic acid monohydrate

→

title compound

(2-(hydroxymethyl)-1,3-dioxan-2-yl)methyl benzoate

Lösungsmittel

ethyl acetate

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGwas stirred at 40° C. overnight
2. 2
   SonstigeTwo reaction mixtures
3. 3
   TrocknenThe organic layer was dried over magnesium sulfate
4. 4
   Filtrationfiltrated
5. 5
   EinengenThe filtrate was concentrated under reduced pressure
6. 6
   workup.DISSOLUTIONThe residue was dissolved in n-heptane/ethyl acetate (2/1)
7. 7
   Waschentoluene and subjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=3/2)

Vorschrift

A mixture of the mixture (0.5 g) containing 3-hydroxy-2-oxopropyl benzoate, 1,3-propanediol (0.932 ml, 12.9 mmol), triethyl orthoformate (0.428 ml, 2.58 mmol), and p-toluenesulfonic acid monohydrate (44.5 mg, 0.234 mmol) was stirred at room temperature for 4 days. Another mixture consisting of the mixture (4 g) containing 3-hydroxy-2-oxopropyl benzoate, 1,3-propanediol (7.46 ml, 103 mmol), triethyl orthoformate (3.42 ml, 20.6 mmol), and p-toluenesulfonic acid monohydrate (356 mg, 1.87 mmol) was stirred at 40° C. overnight. Two reaction mixtures were combined, water and ethyl acetate were added, and the organic layer was taken out. The organic layer was dried over magnesium sulfate and filtrated. The filtrate was concentrated under reduced pressure. The residue was dissolved in n-heptane/ethyl acetate (2/1) and toluene and subjected to silica gel column chromatography (elution solvent: n-heptane/ethyl acetate=3/2) to obtain the title compound (4.2 g).

Quelle