Reaktion #5992

Reaktionsgleichung

2-benzyloxy-3-methoxybenzaldehyde

hydantoin

β-alanine

acetic acid

→

5-[[3-Methoxy-2-(phenylmethoxy)phenyl]methylene]-2,4-imidazolidinedione

Ausbeute 84.0%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 6 hours
2. 2
   Filtrationthe separated solid is filtered
3. 3
   Waschenwashed well with water, methanol

Vorschrift

A solution of 96.90 g (0.40 mole) of 2-benzyloxy-3-methoxybenzaldehyde, 48.04 g (0.48 mole) of hydantoin, 8.02 g (0.09 mole) of β-alanine, and 200 mL of glacial acetic acid is stirred at reflux for 6 hours. Water (500 mL) is added and the separated solid is filtered, washed well with water, methanol, and then ether; wt 109.00 g (84% yield); mp 210-212° C.

Quelle