Reaktion #59909

Reaktionsgleichung

triethylamine

pentaerythritol

triethyl orthoacetate

p-toluenesulfonic acid monohydrate

→

title compound

Ausbeute 48.2%

(1-methyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol

Ausbeute 48.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe temperature of the mixture was further raised to 130° C.
2. 2
   workup.STIRRINGthe mixture was stirred for 30 minutes
3. 3
   Einengenthe reaction mixture was concentrated
4. 4
   SonstigeThe residue was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate)

Vorschrift

A mixture of pentaerythritol (15 g, 110 mmol), triethyl orthoacetate (20.2 ml, 110 mmol), and p-toluenesulfonic acid monohydrate (947 mg, 5.5 mmol) was stirred at 100° C. for 30 minutes. The temperature of the mixture was further raised to 130° C. and the mixture was stirred for 30 minutes. To the reaction mixture, triethylamine (1.53 ml, 11 mmol) was added and the reaction mixture was concentrated. The residue was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate) to obtain the title compound (8.5 g, yield: 48.2%) as a light yellow solid.

Quelle