Reaktion #59868

Reaktionsgleichung

(3-methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methanol

triethylamine

sodium hydrogen carbonate

2-mercaptobenzimidazole

sodium hydroxide

methanesulfonyl chloride

→

title compound

Ausbeute 85.0%

2-(((3-methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)thio)-1H-benzimidazole

Ausbeute 85.0%

Lösungsmittel

THF

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   Temperaturunder cooling in an ice-salt bath
3. 3
   ExtraktionThe aqueous layer was extracted with ethyl acetate
4. 4
   Waschenwashed with water
5. 5
   Trocknena saline solution, dried over anhydrous sodium sulfate
6. 6
   Einengenconcentrated
7. 7
   workup.DISSOLUTIONThe obtained residue was dissolved in ethanol (6 ml)
8. 8
   workup.STIRRINGstirred at room temperature for 16.5 hours
9. 9
   EinengenAfter the reaction mixture was concentrated
10. 10
    workup.ADDITIONNH silica gel was added to the residue
11. 11
    Sonstigethe mixture was dried
12. 12
    SonstigeThe obtained crude product
13. 13
    Sonstigewas purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate=1/0, 1/1-0/1 gradient)
14. 14
    Einengendesired fractions were concentrated

Vorschrift

To a THF (7 ml) solution of the (3-methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methanol (312 mg, 1.00 mmol) obtained in the step (5e), triethylamine (0.30 ml, 2.15 mmol) was added at room temperature, and then methanesulfonyl chloride (0.12 ml, 1.55 mmol) was added under cooling in an ice-salt bath and stirred for 30 minutes in the same conditions. To the reaction mixture, a saturated aqueous solution of sodium hydrogen carbonate and ethyl acetate were added. The aqueous layer was extracted with ethyl acetate. Organic layers were combined, washed with water and a saline solution, dried over anhydrous sodium sulfate, and concentrated. The obtained residue was dissolved in ethanol (6 ml). To the resultant solution, 2-mercaptobenzimidazole (150 mg, 1.00 mmol) and sodium hydroxide (160 mg, 4.00 mmol) were added and stirred at room temperature for 16.5 hours. After the reaction mixture was concentrated, NH silica gel was added to the residue and the mixture was dried. The obtained crude product was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate=1/0, 1/1-0/1 gradient) and desired fractions were concentrated to obtain the title compound (377 mg, 85.0% yield) as a white foam.

Quelle