Reaktion #598504

ord-01d4bca9979a447e994ce22f9fca3c59

Reaktionsgleichung

CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC
diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
Compound 128A
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
→
CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(C(=O)O)c4c3C(=O)N(C)C4)n2)c(OC)c1)OCC
title compound
CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(C(=O)O)c4c3C(=O)N(C)C4)n2)c(OC)c1)OCC
7-{[2-({4-[(Diethoxyphosphoryl)methyl]-2-methoxyphenyl}amino)-5-(trifluoromethyl)pyrimidin-4-yl]amino}-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Edukte

CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC
diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
Compound 128A
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
—
( 100 )

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared using the procedure from Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and Compound 128A. MS (ES+): m/z 624.19 (100) [MH+]; HPLC: tR=1.07 min (UPLC, purity).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09096624B2uspto-grants-2015_08