Reaktion #598503

ord-90ff44e86d8349c4b9abbd8ada76d88d

Reaktionsgleichung

CN1Cc2c(C(=O)O)ccc(NC(=O)OC(C)(C)C)c2C1=O
Compound 116C
CN1Cc2c(C(=O)O)ccc(NC(=O)OC(C)(C)C)c2C1=O
7-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
O=C(O)C(F)(F)F
TFA
→
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
title compound
CN1Cc2c(C(=O)O)ccc(N)c2C1=O
7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Edukte

CN1Cc2c(C(=O)O)ccc(NC(=O)OC(C)(C)C)c2C1=O
Compound 116C
CN1Cc2c(C(=O)O)ccc(NC(=O)OC(C)(C)C)c2C1=O
7-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
O=C(O)C(F)(F)F
TFA

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product was taken on to the next step without purification

Vorschrift

The title compound was prepared by deprotecting Compound 116C with TFA. The crude product was taken on to the next step without purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09096624B2uspto-grants-2015_08