Reaktion #59834

Reaktionsgleichung

trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester

methylmagnesiumbromide

lithium bromide

→

aimed compound

Ausbeute 47.0%

2-bromo-6-methylnaphthalene

Ausbeute 47.0%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith cooling pipe
2. 2
   SonstigeAfter the reaction terminated
3. 3
   workup.ADDITIONadding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution
4. 4
   Sonstigean organic layer was separated
5. 5
   Waschenwashed with the use of sodium bicarbonate solution and sodium chloride solution
6. 6
   Trocknenby drying with the use of magnesium sulfate
7. 7
   SonstigeAfter removing the solvent
8. 8
   workup.DISTILLATIONby distillation
9. 9
   Sonstigeby means of a rotary evaporator

Vorschrift

Under an atmospheric argon gas flow, trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester in an amount of 32 g (90 mmol), dichloro(diphenylphosphinoferrocene)palladium in an amount of 3.6 g (5% by mol), lithium bromide in an amount of 7.8 g (90 mmol) and desiccated tetrahydrofuran in an amount of 100 milliliter were placed into a three neck flask with cooling pipe and having a capacity of 500 milliliter, and then, the resultant solution was cooled down to −20° C. After slowly dripping methylmagnesiumbromide in an amount of 90 milliliter (90 mmol, 1 mol/liter (tetrahydrofuran)) into the flask, the resultant solution was stirred under heating at the temperature of 80° C. for 4 hours. After the reaction terminated, adding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution, an organic layer was separated and washed with the use of sodium bicarbonate solution and sodium chloride solution, followed by drying with the use of magnesium sulfate. After removing the solvent by distillation by means of a rotary evaporator, the resultant crude product was refined by means of column chromatography (silicagel, hexane/dichloromethane=90/10), and as a result, 9.4 g of aimed compound (white crystal) was obtained (yield: 47%).

Quelle