Reaktion #59807

Reaktionsgleichung

5-Nitro-2H-pyrazole-3-carboxylic acid

sodium bicarbonate

→

title product

5-Nitro-2H-pyrazole-3-carboxylic acid methyl ester

Lösungsmittel

sulfuric acid methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted with ethyl acetate three times

Vorschrift

A solution of 5-Nitro-2H-pyrazole-3-carboxylic acid (5 gm, 32 mmol) in 100 ml of 2% sulfuric acid methanol was refluxed for 20 hours. The mixture was cooled to room temperature and added to saturated sodium bicarbonate. The mixture was extracted with ethyl acetate three times to obtain 3.59 gm of title product after drying over magnesium sulfate, filtering and evaporating to dryness. ESI M+1=171.

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