Reaktion #597849

Reaktionsgleichung

tert-Butyl 2-(4-chlorophenyl)cyclopropylcarbamate

HCl

dioxane

→

title compound

Ausbeute 198.2%

2-(4-chlorophenyl)cyclopropanamine hydrochloride

Ausbeute 198.2%

Lösungsmittel

Dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprecipitated out of solution
2. 2
   EinengenThe crude mixture was concentrated
3. 3
   SonstigeThe residual fine solid was dried under high vacuum

Vorschrift

tert-Butyl 2-(4-chlorophenyl)cyclopropylcarbamate (51.9 mg, 0.1938 mmol) was dissolved in Dichloromethane (1 ml) and 4M HCl solution in dioxane (0.4846 ml, 1.938 mmol) was added. The mixture was stirred for 3 hours at ambient temperature, during which time a white solid precipitated out of solution. The crude mixture was concentrated and chased with EtOAc (2×10 ml). The residual fine solid was dried under high vacuum to provide 39.2 mg of the title compound as a solid (99%).

Quelle