Reaktion #5974

Reaktionsgleichung

methyl 2-methoxy-4-amino-5-chlorobenzoate

acetic acid

→

methyl 2-methoxy-4-acetylamino-5-chlorobenzoate

Lösungsmittel

acetic anhydride

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture is filtered
2. 2
   workup.ADDITIONdiluted with water
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated to dryness

Vorschrift

A mixture of 21 g of methyl 2-methoxy-4-amino-5-chlorobenzoate is stirred in 12 ml acetic anhydride and 100 ml acetic acid at 100° C. for 24 hours. The reaction mixture is filtered, diluted with water, filtered and evaporated to dryness to obtain methyl 2-methoxy-4-acetylamino-5-chlorobenzoate which is used directly in the next step.

Quelle