Reaktion #597285

Reaktionsgleichung

compound

N-(5-Carbamoylpyrimidin-4-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

→

2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimido[4,5-d]pyrimidin-4-ol

Lösungsmittel

N,N-dimethylacetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe reaction mixture was poured onto ice-water
2. 2
   Filtrationfiltered
3. 3
   WaschenThe filter residue was washed with water
4. 4
   Sonstigedried under high vacuum at 50° C. overnight

Vorschrift

246 mg (0.629 mmol) of the compound from example 48A were initially charged in N,N-dimethylacetamide (22 ml) and stirred in a microwave at 220° C. for 30 min. The reaction mixture was poured onto ice-water and filtered. The filter residue was washed with water and dried under high vacuum at 50° C. overnight. This gave 142 mg (57% of theory) of the title compound in solid form.

Quelle