Reaktion #5970

Reaktionsgleichung

thionyl chloride

5-chlorosalicylic acid

methanol

→

methyl 5-chlorosalicylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThis is then refluxed overnight
2. 2
   Sonstigethe solvent removed
3. 3
   workup.DISSOLUTIONthe residue dissolved in ether
4. 4
   WaschenThe ether is washed with a sodium bicarbonate solution, water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Sonstigeevaporated to dryness

Vorschrift

To a cold solution of 100 ml methanol is slowly added 100 ml thionyl chloride followed by 30 g of 5-chlorosalicylic acid. This is then refluxed overnight, the solvent removed and the residue dissolved in ether. The ether is washed with a sodium bicarbonate solution, water, dried over magnesium sulfate and evaporated to dryness to obtain methyl 5-chlorosalicylate which is used directly in the next step.

Quelle