Reaktion #59699

Reaktionsgleichung

Ammonium chloride

t-Butyloxycarbonylhydrazine

4-bromobenzoyl chloride

DIPEA

DCM

→

4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic phase was separated
2. 2
   Sonstigedried
3. 3
   Sonstigethe solvent evaporated under vacuum

Vorschrift

t-Butyloxycarbonylhydrazine (1.26 g) was added portionwise to a solution of 4-bromobenzoyl chloride (2.0 g), and DIPEA (2.37 ml) in DCM (20 ml) and the reaction stirred at room temperature for 18 hours. Ammonium chloride solution was added, the organic phase was separated, dried and the solvent evaporated under vacuum to give 4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide.

Quelle