Reaktion #59683

Reaktionsgleichung

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole

Intermediate 7

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole

potassium iodide

piperidine

→

1-[5-(4-Iodophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe amine was then removed in vacuo
2. 2
   Sonstigethe product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol)

Vorschrift

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in piperidine (2 ml) and stirred for 18 hours at 20° C. The amine was then removed in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).

Quelle