Reaktion #59634

Reaktionsgleichung

2-chloro-5-nitroanisole

THF

→

expected product

Ausbeute 92.6%

4-Chloro-3-methoxyaniline

Ausbeute 92.6%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst is filtered off over Celite®
2. 2
   Einengenthe filtrate is concentrated under vacuum

Vorschrift

A mixture of 36 g of 2-chloro-5-nitroanisole and Raney nickel® in 150 ml of MeOH and 200 ml of THF is hydrogenated in Parr apparatus for 4 hours, at 35° C. and under a pressure of 1.3 bar. The catalyst is filtered off over Celite® and the filtrate is concentrated under vacuum. 28 g of the expected product are obtained and are used without further purification.

Quelle