Reaktion #59621

Reaktionsgleichung

2-bromophenol

diethyl sulphate

→

expected product

1-Bromo-2-ethoxybenzene

Lösungsmittel

NaOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 2 hours
2. 2
   Extraktionit is extracted with EtOAc
3. 3
   Waschenthe organic phase is washed with 2N NaOH solution
4. 4
   Trocknendried over Na2SO4
5. 5
   Sonstigethe solvent is evaporated off under vacuum

Vorschrift

A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.

Quelle