Reaktion #596017

Reaktionsgleichung

ammonia

2-fluoro-4-(trifluoromethyl)benzoic acid

oxalyl chloride

→

title compound

2-fluoro-4-(trifluoromethyl)benzamide

Lösungsmittel

THF

Reaktionsbedingungen

Vorschrift

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-fluoro-4-(trifluoromethyl)benzoic acid (1.5 g), THF (25 mL), oxalyl chloride (0.5 mL) and ammonia gas to afford 1.35 g of the product. 1H NMR (300 MHz, DMSO d6): δ 7.65 (d, J=8.4 Hz, 1H), 7.77-7.84 (m, 3H), 7.96 (br s, 1H); MS (m/z): 208.06 (M+).

Quelle